Distribution, Metabolism, Excretion, and Lactational Transfer to Pups of Tetrabromobisphenol A and Its Metabolites in C57BL/6 Mice

We characterized the absorption, distribution, metabolism, and excretion of tetrabromobisphenol A (TeBBPA) in C57BL/6 mice. After TeBBPA dosing, we monitored mice collected samples for 24 h. Most was excreted feces at 12 At h, 71% administered found TeBBPA-conjugates were detected 17.8%. also debrominated metabolites TeBBPA, including tribromobisphenol (TriBBPA), dibromobisphenol (DiBBPA), monobromobisphenol (MoBBPA). TriBBPA, 2,2′-DiBBPA MoBBPA dam’s blood between 30 min 1 Moreover, TriBBPA milk min. The primary formed by conjugation, whereas debromination represented a minor metabolism pathway. our findings demonstrated that parent compound its distributed into maternal transferred to nursing pups following oral administration.